5-Liquid Preparation System - SKE & EAGLE GROUP LIMITED

Liquid Preparation System

Eagle’s Liquid Preparation System (LPS) is a high-end automated platform that integrates precision, efficiency, and compliance. At its heart, it employs advanced process design to achieve precise weighing, transfer, and homogeneous mixing of diverse materials, perfectly meeting the stringent production standards from Small Volume (SVP) to Large Volume Parenteral (LVP) in the pharmaceutical industry. With seamlessly integrated Clean-in-Place (CIP) and Sterilize-in-Place (SIP) capabilities, it significantly reduces the risk of cross-contamination and manual errors while guaranteeing superior final product quality, sterility, and high production batch-to-batch consistency. Furthermore, its flexible modular design allows for easy adaptation to varying production scales and process changes, making it an ideal solution for enhancing the production capabilities of modern smart factories.

Wide Use of Liquid Preparation System

The Liquid Preparation System (LPS) is a versatile platform with extremely broad application range. It is primarily employed in industries that demand stringent requirements for liquid formulation accuracy and hygienic standards. These include the pharmaceutical industry (e.g., production of injections and infusions), biotechnology (e.g., preparation of cell culture media and buffers), the food and beverage industry (e.g., blending of flavorings, concentrated juices, and dairy products), and the cosmetics industry (e.g., precise mixing of emulsions, serums, and lotions). Furthermore, it also plays a critical role in the chemical industry and some specialty chemical sectors.

Work Principle

The working principle of the Liquid Preparation System (LPS) can be summarized into the following four core steps:

Precise Dosing: Per recipe, the central control system automatically uses high-precision devices (metering pumps, flow meters, load cells) to transfer liquid ingredients into the mixing vessel in exact proportions and sequences.
Efficient Mixing: Agitators in the mixing vessel blend materials efficiently and homogeneously at optimized settings; the system monitors and adjusts temperature, pressure, etc., to ensure mixing quality.
In-line Processing & QC: Post-mixing, the product may undergo in-line processing (e.g., pH adjustment, filtration, temperature control) in a closed system, with continuous quality monitoring via integrated sensors.
Automatic Cleaning & Sterilization: After production, integrated CIP/SIP systems automatically clean and sterilize product-contact pipes/vessels, prepping for the next batch and ensuring sterility.

Product Feature

Customized & Compliant Design

Tailored to the client's specific site layout and sterilization requirements, with strict adherence to international standards such as GMP, ISPE engineering guidelines, and FDA regulations, ensuring the system meets all regulatory and validation requirements from the outset.

Optimized Space & Ergonomic Operation

Utilizes a compact, modular layout to significantly optimize the equipment footprint. The intuitive Human-Machine Interface (HMI) with clear operational logic greatly reduces complexity and labor intensity for operators.

Exceptional Sanitary Design & Materials

Employs high-purity sanitary materials (e.g., 304 or 316L stainless steel) for core pipelines and components, with surfaces electropolished. Automatic welding techniques ensure all connections are smooth, free of dead legs and residue, eliminating contamination risks.

Precise Process Control & Safety Assurance

Integrates high-precision sensors and automated valves for precise control of critical parameters like flow, temperature, and pressure. A rational reflux design equipped with anti-mixing valves effectively prevents cross-contamination, ensuring process repeatability and final product quality.

Relative Products

Multi-Effect Water Distiller

Multi-effect water distiller adopted the purified water as the feed water, produced WFI (water for injection) by heating industrial steam. Eagle’s LDS series Multi Effect Still adopted the purified water as the feed water, produced WFI by heating industrial steam. The product satisfies the requirement of USP,EP and JP.

Purified Water Generator Two Stage RO System with EDI

Eagle has been at the forefront of water treatment innovation for nearly 70 years, specializing in advanced Purified Water Generation systems tailored for the pharmaceutical industry. Our comprehensive turnkey solutions seamlessly transform raw tap water into high-purity water, optional with integrated storage and distribution systems.

CIP & SIP

Our Cleaning in Place (CIP)/Sterilizing in Place (SIP) systems are engineered to your specific application, facility layout and utility requirements for effective and efficient sanitary process equipment and process pipings cleaning in pharmaceutical, biotechnology, nutraceutical and personal care industries.

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