CIP & SIP
In the pharmaceutical and medical industries, the Clean-in-Place (CIP) and Sterilizing-in-Place (SIP) systems operate as an integrated automation suite—rarely used independently—forming a core “cleaning-sterilization” loop for equipment (e.g., reactors, pipelines). The CIP system cleans equipment in-situ without disassembly: it removes product residues and reduces microbes to prevent cross-contamination, meets GMP traceability requirements, and boosts efficiency by avoiding manual disassembly errors.
Complementing CIP, the SIP system achieves post-cleaning sterility in-situ (via saturated steam or validated disinfectants), eliminating all microbes (including spores) to meet the <10⁻⁶ survival probability standard. This CIP-SIP combination ensures product safety, complies with strict regulations, and streamlines workflows—automated switching cuts downtime, critical for aseptic production like injectables or medical device manufacturing.
Wide Use of CIP & SIP
CIP (Clean-in-Place) and SIP (Sterilize-in-Place) systems are widely used in pharmaceuticals (e.g., injectable reactors, infusion bottle filling machine pipelines), medical care (e.g., surgical instrument cleaning and sterilization equipment, biological sample storage tanks), and food processing (e.g., dairy fermentation tanks, beverage delivery pipelines). They are particularly suitable for scenarios requiring no equipment disassembly, high cleanliness/sterility, and compliance with regulations like GMP, ensuring product safety and production efficiency through an automated “cleaning-sterilization” closed loop.
Work Principle
- Pre-rinsing: Use purified water to remove loose residues in the equipment, preparing for cleaning;
- Main cleaning (CIP core): Circulate cleaning agents to remove dirt and some microorganisms via mechanical force + chemical action;
- Rinsing: Rinse residual cleaning agents with purified water to ensure no chemical residues;
- Air removal & heating (SIP pre-step): Discharge air from the equipment, and introduce saturated steam to raise to sterilization temperature (e.g., 121℃);
- Sterilization holding (SIP core): Maintain constant temperature for a specified time to kill all microorganisms including spores;
- Drying & sterility maintenance: Discharge condensed water, dry with sterile air, and keep the equipment sterile.
Product Feature
- Wide Adaptability: Suitable for cleaning/sterilizing large, medium, and small-scale equipment, compatible with tanks, pipelines, reactors and other production equipment, covering pharmaceuticals, medical care, food and other fields;
- High Efficiency & Energy Saving: CIP cleaning agents recyclable, external circulation system reduces water, electricity and chemical consumption; SIP mainly uses saturated steam, with fast sterilization speed and no chemical residues, lowering subsequent processing costs;
- Safety & Low Contamination: The entire process (CIP cleaning → SIP sterilization) is completed in sealed equipment, avoiding human contact contamination, significantly reducing material cross-contamination and secondary contamination risks;
- Convenience & Easy Maintenance: Compact overall structure, small footprint, no complex modification required for installation; core components have low wear, daily maintenance only needs routine inspection, long service life;
- Flexibility & Controllability: CIP offers single-tank/double-tank/multi-tank configurations, providing fixed and mobile types to adapt to different workshop layouts; CIP cleaning procedures can be preset for automatic operation, SIP sterilization temperature (e.g., 121℃/132℃) and holding time precisely controllable, with traceable data;
- Collaborative Compliance: CIP and SIP can seamlessly connect to form a “cleaning-sterilization” closed loop, meeting GMP, FDA and other regulatory requirements for cleanliness and sterility verification, facilitating industry compliance review;
Relative Products
Multi-Effect Water Distiller
Multi-effect water distiller adopted the purified water as the feed water, produced WFI (water for injection) by heating industrial steam. Eagle’s LDS series Multi Effect Still adopted the purified water as the feed water, produced WFI by heating industrial steam. The product satisfies the requirement of USP,EP and JP.
Water Storage & Distribution System
Eagle skid-mounted assemblies integrate all monitoring instruments and control devices for the WFI distribution system into a compact unit, which is fully assembled and integrated with a PLC (Programmable Logic Controller) system.
Purified Water Generator Two Stage RO System with EDI
Eagle has been at the forefront of water treatment innovation for nearly 70 years, specializing in advanced Purified Water Generation systems tailored for the pharmaceutical industry. Our comprehensive turnkey solutions seamlessly transform raw tap water into high-purity water, optional with integrated storage and distribution systems.
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